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Direct, Catalytic and Regioselective Synthesis of 2-Alkyl, Aryl, and Alkenyl-Substituted N-Heterocycles from N-Oxides

A one-step transformation of heterocyclic N-oxides to 2-alkyl, aryl, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of copper catalysis and activation by lithium fluoride or magnesium chloride. The utility of this method for...

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Detalhes bibliográficos
Main Authors: Larionov, Oleg V., Stephens, David, Mfuh, Adelphe, Chavez, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134923/
https://ncbi.nlm.nih.gov/pubmed/24410049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol403631k
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