TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

Microglia (tissue-resident macrophages) represent the main cell type of the innate immune system in the CNS; however, the mechanisms that control the activation of microglia are widely unknown. We systematically explored microglial activation and functional microglia–neuron interactions in organotyp...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Papageorgiou, Ismini E., Lewen, Andrea, Galow, Lukas V., Cesetti, Tiziana, Scheffel, Jörg, Regen, Tommy, Hanisch, Uwe-Karsten, Kann, Oliver
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711883/
https://ncbi.nlm.nih.gov/pubmed/26699475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513853113
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