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TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ
Microglia (tissue-resident macrophages) represent the main cell type of the innate immune system in the CNS; however, the mechanisms that control the activation of microglia are widely unknown. We systematically explored microglial activation and functional microglia–neuron interactions in organotyp...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4711883/ https://ncbi.nlm.nih.gov/pubmed/26699475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513853113 |
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