GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ

Abstract Background The granulocyte-macrophage colony-stimulating factor (GM-CSF) (or CSF-2) is involved in myeloid cell growth and differentiation, and, possibly, a major mediator of inflammation in body tissues. The role of GM-CSF in the activation of microglia (CNS resident macrophages) and the c...

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Detalhes bibliográficos
Main Authors: Hasan Onur Dikmen, Marc Hemmerich, Andrea Lewen, Jan-Oliver Hollnagel, Bruno Chausse, Oliver Kann
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-08-01
Colecção:Journal of Neuroinflammation
Assuntos:
Cytokines
Electrophysiology
GM-CSF
Hippocampus
Innate immunity
Microglia
Acesso em linha:http://link.springer.com/article/10.1186/s12974-020-01903-4
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