Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics

BACKGROUND: Carcinogenic hexavalent chromium [Cr(VI)] requires cellular reduction to generate DNA damage. Metabolism of Cr(VI) by its principal reducer ascorbate (Asc) lacks a Cr(V) intermediate, which is abundant in reactions with a minor reducing agent, glutathione. Cultured cells are widely used...

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Bibliografiska uppgifter
I publikationen:Environ Health Perspect
Huvudupphovsmän: Luczak, Michal W., Green, Samantha E., Zhitkovich, Anatoly
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Institute of Environmental Health Sciences 2015
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710604/
https://ncbi.nlm.nih.gov/pubmed/25977998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1409434
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