Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

Immunotherapy is one of the key strategies for cancer treatment. The cGAS-cGAMP-STING-IRF3 pathway of cytosolic DNA sensing plays a pivotal role in antiviral defense. We report that the STING activator cGAMP possesses significant antitumor activity in mice by triggering the STING-dependent pathway d...

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Vydáno v:Sci Rep
Hlavní autoři: Li, Tiejun, Cheng, Hao, Yuan, Hong, Xu, Qiming, Shu, Chang, Zhang, Yuefan, Xu, Pengbiao, Tan, Jason, Rui, Yaocheng, Li, Pingwei, Tan, Xiangshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709567/
https://ncbi.nlm.nih.gov/pubmed/26754564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19049
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