Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent metastasis. Here we generated an E-cadherin-GFP mous...

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Publicado no:Cell Rep
Main Authors: Erami, Zahra, Herrmann, David, Warren, Sean C., Nobis, Max, McGhee, Ewan J., Lucas, Morghan C., Leung, Wilfred, Reischmann, Nadine, Mrowinska, Agata, Schwarz, Juliane P., Kadir, Shereen, Conway, James R.W., Vennin, Claire, Karim, Saadia A., Campbell, Andrew D., Gallego-Ortega, David, Magenau, Astrid, Murphy, Kendelle J., Ridgway, Rachel A., Law, Andrew M., Walters, Stacey N., Grey, Shane T., Croucher, David R., Zhang, Lei, Herzog, Herbert, Hardeman, Edna C., Gunning, Peter W., Ormandy, Christopher J., Evans, T.R. Jeffry, Strathdee, Douglas, Sansom, Owen J., Morton, Jennifer P., Anderson, Kurt I., Timpson, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709331/
https://ncbi.nlm.nih.gov/pubmed/26725115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.020
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