Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent metastasis. Here we generated an E-cadherin-GFP mous...

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Vydáno v:Cell Rep
Hlavní autoři: Erami, Zahra, Herrmann, David, Warren, Sean C., Nobis, Max, McGhee, Ewan J., Lucas, Morghan C., Leung, Wilfred, Reischmann, Nadine, Mrowinska, Agata, Schwarz, Juliane P., Kadir, Shereen, Conway, James R.W., Vennin, Claire, Karim, Saadia A., Campbell, Andrew D., Gallego-Ortega, David, Magenau, Astrid, Murphy, Kendelle J., Ridgway, Rachel A., Law, Andrew M., Walters, Stacey N., Grey, Shane T., Croucher, David R., Zhang, Lei, Herzog, Herbert, Hardeman, Edna C., Gunning, Peter W., Ormandy, Christopher J., Evans, T.R. Jeffry, Strathdee, Douglas, Sansom, Owen J., Morton, Jennifer P., Anderson, Kurt I., Timpson, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709331/
https://ncbi.nlm.nih.gov/pubmed/26725115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.020
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