FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification ha...

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Bibliografiset tiedot
Julkaisussa:PLoS Biol
Päätekijät: Scholz, Carsten C., Rodriguez, Javier, Pickel, Christina, Burr, Stephen, Fabrizio, Jacqueline-alba, Nolan, Karen A., Spielmann, Patrick, Cavadas, Miguel A. S., Crifo, Bianca, Halligan, Doug N., Nathan, James A., Peet, Daniel J., Wenger, Roland H., Von Kriegsheim, Alex, Cummins, Eoin P., Taylor, Cormac T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709136/
https://ncbi.nlm.nih.gov/pubmed/26752685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002347
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