FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification ha...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Scholz, Carsten C., Rodriguez, Javier, Pickel, Christina, Burr, Stephen, Fabrizio, Jacqueline-alba, Nolan, Karen A., Spielmann, Patrick, Cavadas, Miguel A. S., Crifo, Bianca, Halligan, Doug N., Nathan, James A., Peet, Daniel J., Wenger, Roland H., Von Kriegsheim, Alex, Cummins, Eoin P., Taylor, Cormac T.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709136/
https://ncbi.nlm.nih.gov/pubmed/26752685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002347
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