FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification ha...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Scholz, Carsten C., Rodriguez, Javier, Pickel, Christina, Burr, Stephen, Fabrizio, Jacqueline-alba, Nolan, Karen A., Spielmann, Patrick, Cavadas, Miguel A. S., Crifo, Bianca, Halligan, Doug N., Nathan, James A., Peet, Daniel J., Wenger, Roland H., Von Kriegsheim, Alex, Cummins, Eoin P., Taylor, Cormac T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709136/
https://ncbi.nlm.nih.gov/pubmed/26752685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002347
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