Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable Protective Immune Response in Hamsters

BACKGROUND: Visceral leishmaniasis (VL) is a neglected tropical disease and is fatal if untreated. There is no vaccine available against leishmaniasis. The majority of patients with cutaneous leishmaniasis (CL) or VL develop a long-term protective immunity after cure from infection, which indicates...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Fiuza, Jacqueline Araújo, Dey, Ranadhir, Davenport, Dwann, Abdeladhim, Maha, Meneses, Claudio, Oliveira, Fabiano, Kamhawi, Shaden, Valenzuela, Jesus G., Gannavaram, Sreenivas, Nakhasi, Hira L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4708988/
https://ncbi.nlm.nih.gov/pubmed/26752686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004322
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