Centrin-Deleted Leishmania donovani Parasites Help CD4(+) T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200–CD200R Immune Inhibitory Axis

The protozoan parasite Leishmania has evolved several strategies to undermine host defense mechanisms by inducing Th2-type adaptive immunity and suppressing effector functions of Th1 phenotype. In our earlier studies, using centrin gene-deleted Leishmania (LdCen(−/−)) parasites as an immunogen, we h...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Singh, Rakesh K., Gannavaram, Sreenivas, Ismail, Nevien, Kaul, Amit, Gedda, Mallikarjuna Rao, Nakhasi, Hira L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994488/
https://ncbi.nlm.nih.gov/pubmed/29915577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01176
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