High-Throughput Screening for Internalizing Antibodies by Homogeneous Fluorescence Imaging of a pH-Activated Probe

Antibody-drug conjugates (ADCs) represent a rapidly growing class of biotherapeutics that deliver drugs specifically to target cells by binding of the antibody component to surface receptors. The majority of ADCs require receptor internalization depending on intrinsic features of the specific ADC-an...

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Udgivet i:J Biomol Screen
Main Authors: Riedl, Thilo, van Boxtel, Egon, Bosch, Martijn, Parren, Paul W. H. I., Gerritsen, Arnout F.
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4708616/
https://ncbi.nlm.nih.gov/pubmed/26518032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057115613270
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