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A Cell-Based Internalization and Degradation Assay with an Activatable Fluorescence–Quencher Probe as a Tool for Functional Antibody Screening

For the development of therapeutically potent anti-cancer antibody drugs, it is often important to identify antibodies that internalize into cells efficiently, rather than just binding to antigens on the cell surface. Such antibodies can mediate receptor endocytosis, resulting in receptor downregula...

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Bibliografische gegevens
Gepubliceerd in:J Biomol Screen
Hoofdauteurs: Li, Yan, Liu, Peter Corbett, Shen, Yang, Snavely, Marshall D., Hiraga, Kaori
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: SAGE Publications 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512523/
https://ncbi.nlm.nih.gov/pubmed/26024945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057115588511
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