A Cell-Based Internalization and Degradation Assay with an Activatable Fluorescence–Quencher Probe as a Tool for Functional Antibody Screening

For the development of therapeutically potent anti-cancer antibody drugs, it is often important to identify antibodies that internalize into cells efficiently, rather than just binding to antigens on the cell surface. Such antibodies can mediate receptor endocytosis, resulting in receptor downregula...

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Detaylı Bibliyografya
Yayımlandı:J Biomol Screen
Asıl Yazarlar: Li, Yan, Liu, Peter Corbett, Shen, Yang, Snavely, Marshall D., Hiraga, Kaori
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: SAGE Publications 2015
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512523/
https://ncbi.nlm.nih.gov/pubmed/26024945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057115588511
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