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Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H(2)S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells,...

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Bibliografiske detaljer
Udgivet i:Medchemcomm
Main Authors: Niu, Weining, Wu, Ping, Chen, Fei, Wang, Jun, Shang, Xiaoya, Xu, Chunlan
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072345/
https://ncbi.nlm.nih.gov/pubmed/30108705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00493h
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