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Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H(2)S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells,...

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Bibliografski detalji
Izdano u:Medchemcomm
Glavni autori: Niu, Weining, Wu, Ping, Chen, Fei, Wang, Jun, Shang, Xiaoya, Xu, Chunlan
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072345/
https://ncbi.nlm.nih.gov/pubmed/30108705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00493h
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