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The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
Here, we show that the synaptic vesicle protein SV2A is the brain binding site of levetiracetam (LEV), a new antiepileptic drug with a unique activity profile in animal models of seizure and epilepsy. The LEV-binding site is enriched in synaptic vesicles, and photoaffinity labeling of purified synap...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2004
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC470764/ https://ncbi.nlm.nih.gov/pubmed/15210974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308208101 |
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