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Levetiracetam Reverses Synaptic Deficits Produced by Overexpression of SV2A

Levetiracetam is an FDA-approved drug used to treat epilepsy and other disorders of the nervous system. Although it is known that levetiracetam binds the synaptic vesicle protein SV2A, how drug binding affects synaptic functioning remains unknown. Here we report that levetiracetam reverses the effec...

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Hlavní autoři: Nowack, Amy, Malarkey, Erik B., Yao, Jia, Bleckert, Adam, Hill, Jessica, Bajjalieh, Sandra M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248421/
https://ncbi.nlm.nih.gov/pubmed/22220214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029560
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