Levetiracetam Reverses Synaptic Deficits Produced by Overexpression of SV2A

Levetiracetam is an FDA-approved drug used to treat epilepsy and other disorders of the nervous system. Although it is known that levetiracetam binds the synaptic vesicle protein SV2A, how drug binding affects synaptic functioning remains unknown. Here we report that levetiracetam reverses the effec...

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Bibliographic Details
Main Authors: Nowack, Amy, Malarkey, Erik B., Yao, Jia, Bleckert, Adam, Hill, Jessica, Bajjalieh, Sandra M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248421/
https://ncbi.nlm.nih.gov/pubmed/22220214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029560
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