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An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. Multiple genetic loci contribute to disease susceptibility in humans, with the most responsible locus being the major histocompatibility complex (MHC). Certain MHC alleles...

詳細記述

保存先:
書誌詳細
出版年:J Diabetes Res
主要な著者: Babad, Jeffrey, Ali, Riyasat, Schloss, Jennifer, DiLorenzo, Teresa P.
フォーマット: Artigo
言語:Inglês
出版事項: Hindawi Publishing Corporation 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707332/
https://ncbi.nlm.nih.gov/pubmed/26824049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/7959060
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