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Beyond HLA-A*0201: New HLA-transgenic NOD Mouse Models of Type 1 Diabetes Identify the Insulin C-peptide As a Rich Source of CD8(+) T Cell Epitopes
Type 1 diabetes is an autoimmune disease characterized by T cell responses to beta cell antigens, including insulin. Investigations employing the NOD mouse model of the disease have revealed an essential role for beta cell-specific CD8(+) T cells in the pathogenic process. As CD8(+) T cells specific...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358524/ https://ncbi.nlm.nih.gov/pubmed/22539795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102930 |
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