Beyond HLA-A*0201: New HLA-transgenic NOD Mouse Models of Type 1 Diabetes Identify the Insulin C-peptide As a Rich Source of CD8(+) T Cell Epitopes

Type 1 diabetes is an autoimmune disease characterized by T cell responses to beta cell antigens, including insulin. Investigations employing the NOD mouse model of the disease have revealed an essential role for beta cell-specific CD8(+) T cells in the pathogenic process. As CD8(+) T cells specific...

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Hlavní autoři: Antal, Zoltan, Baker, Jason C., Smith, Carla, Jarchum, Irene, Babad, Jeffrey, Mukherjee, Gayatri, Yang, Yang, Sidney, John, Sette, Alessandro, Santamaria, Pere, DiLorenzo, Teresa P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358524/
https://ncbi.nlm.nih.gov/pubmed/22539795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102930
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