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Ins2 Deficiency Augments Spontaneous HLA-A*0201-restricted T Cell Responses to Insulin

Type 1 diabetes results from the autoimmune destruction of insulin-producing beta cells by T cells specific for beta cell antigens, including insulin. In humans, the non-MHC locus conferring the strongest disease susceptibility is the insulin gene, and alleles yielding lower thymic insulin expressio...

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Bibliografske podrobnosti
Main Authors: Jarchum, Irene, DiLorenzo, Teresa P.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858386/
https://ncbi.nlm.nih.gov/pubmed/19966211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903414
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