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Ins2 Deficiency Augments Spontaneous HLA-A*0201-restricted T Cell Responses to Insulin
Type 1 diabetes results from the autoimmune destruction of insulin-producing beta cells by T cells specific for beta cell antigens, including insulin. In humans, the non-MHC locus conferring the strongest disease susceptibility is the insulin gene, and alleles yielding lower thymic insulin expressio...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858386/ https://ncbi.nlm.nih.gov/pubmed/19966211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903414 |
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