Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells

For therapeutic cancer vaccination, the adoptive transfer of mRNA-electroporated dendritic cells (DCs) is frequently performed, usually with monocyte-derived, cytokine-matured DCs (moDCs). However, DCs are rich in danger-sensing receptors which could recognize the exogenously delivered mRNA and indu...

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Publicat a:J Immunol Res
Autors principals: Hoyer, Stefanie, Gerer, Kerstin F., Pfeiffer, Isabell A., Prommersberger, Sabrina, Höfflin, Sandra, Jaitly, Tanushree, Beltrame, Luca, Cavalieri, Duccio, Schuler, Gerold, Vera, Julio, Schaft, Niels, Dörrie, Jan
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707322/
https://ncbi.nlm.nih.gov/pubmed/26824052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/952184
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