RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma

BACKGROUND: Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Harrer, Dennis C., Simon, Bianca, Fujii, Shin-ichiro, Shimizu, Kanako, Uslu, Ugur, Schuler, Gerold, Gerer, Kerstin F., Hoyer, Stefanie, Dörrie, Jan, Schaft, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561563/
https://ncbi.nlm.nih.gov/pubmed/28818060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3539-3
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