Identification of selective lead compounds for treatment of high-ploidy breast cancer

Increased ploidy is common in tumors but treatments for tumors with excess chromosome sets are not available. Here, we characterize high-ploidy breast cancers and identify potential anticancer compounds selective for the high-ploidy state. Among 354 human breast cancers, 10% have mean chromosome cop...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Choudhary, Alka, Zachek, Brittany, Lera, Robert F., Zasadil, Lauren M., Lasek, Amber, Denu, Ryan A., Kim, Hyunjung, Kanugh, Craig, Laffin, Jennifer J., Harter, Josephine M., Wisinski, Kari B., Saha, Sandeep, Weaver, Beth A., Burkard, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707107/
https://ncbi.nlm.nih.gov/pubmed/26586723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0527
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