Identification of selective lead compounds for treatment of high-ploidy breast cancer

Increased ploidy is common in tumors but treatments for tumors with excess chromosome sets are not available. Here, we characterize high-ploidy breast cancers and identify potential anticancer compounds selective for the high-ploidy state. Among 354 human breast cancers, 10% have mean chromosome cop...

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Pubblicato in:Mol Cancer Ther
Autori principali: Choudhary, Alka, Zachek, Brittany, Lera, Robert F., Zasadil, Lauren M., Lasek, Amber, Denu, Ryan A., Kim, Hyunjung, Kanugh, Craig, Laffin, Jennifer J., Harter, Josephine M., Wisinski, Kari B., Saha, Sandeep, Weaver, Beth A., Burkard, Mark E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707107/
https://ncbi.nlm.nih.gov/pubmed/26586723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0527
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