Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response

Stress responses are adaptive cellular programs that identify and mitigate potentially dangerous threats. Misfolded proteins are a ubiquitous and clinically relevant stress. Trivalent metalloids, such as arsenic, have been proposed to cause protein misfolding. Using tandem mass tag-based mass spectr...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Guerra-Moreno, Angel, Isasa, Marta, Bhanu, Meera K., Waterman, David P., Eapen, Vinay V., Gygi, Steven P., Hanna, John
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705986/
https://ncbi.nlm.nih.gov/pubmed/26491016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684969
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