Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets

Endothelial cells release prostacyclin (PGI(2)) and nitric oxide (NO) to inhibit platelet functions. PGI(2) and NO effects are mediated by cyclic nucleotides, cAMP- and cGMP-dependent protein kinases (PKA, PKG), and largely unknown PKA and PKG substrate proteins. The small G-protein Rac1 plays a key...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Nagy, Zoltan, Wynne, Kieran, von Kriegsheim, Alexander, Gambaryan, Stepan, Smolenski, Albert
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705978/
https://ncbi.nlm.nih.gov/pubmed/26507661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678003
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