Thrombin and Collagen Induce a Feedback Inhibitory Signaling Pathway in Platelets Involving Dissociation of the Catalytic Subunit of Protein Kinase A from an NFκB-IκB Complex

Protein kinase A (PKA) activation by cAMP phosphorylates multiple target proteins in numerous platelet inhibitory pathways that have a very important role in maintaining circulating platelets in a resting state. Here we show that in thrombin- and collagen-stimulated platelets, PKA is activated by cA...

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Huvudupphovsmän: Gambaryan, Stepan, Kobsar, Anna, Rukoyatkina, Natalia, Herterich, Sabine, Geiger, Joerg, Smolenski, Albert, Lohmann, Suzanne M., Walter, Ulrich
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881761/
https://ncbi.nlm.nih.gov/pubmed/20356841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077602
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