Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts

Disrupting the protective signals provided by the bone marrow microenvironment will be critical for more effective combination drug therapies for acute myeloid leukemia (AML). Cells of the osteoblast lineage that reside in the endosteal niche have been implicated in promoting survival of AML cells....

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Udgivet i:J Biol Chem
Main Authors: Kremer, Kimberly N., Dudakovic, Amel, Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Kaufmann, Scott H., Westendorf, Jennifer J., van Wijnen, Andre J., Hedin, Karen E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705949/
https://ncbi.nlm.nih.gov/pubmed/26491017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668160
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