Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts

Disrupting the protective signals provided by the bone marrow microenvironment will be critical for more effective combination drug therapies for acute myeloid leukemia (AML). Cells of the osteoblast lineage that reside in the endosteal niche have been implicated in promoting survival of AML cells....

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Kremer, Kimberly N., Dudakovic, Amel, Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Kaufmann, Scott H., Westendorf, Jennifer J., van Wijnen, Andre J., Hedin, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705949/
https://ncbi.nlm.nih.gov/pubmed/26491017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668160
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