Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci

Progenitor-B cells recombine their immunoglobulin (Ig) loci to create unique antigen receptors. Despite a common recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner. We studied pre-pro-B cells and Rag(−/−) progenitor-B cells to determine whether Ig locus cont...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Rother, Magdalena B., Palstra, Robert-Jan, Jhunjhunwala, Suchit, van Kester, Kevin A. M., van IJcken, Wilfred F. J., Hendriks, Rudi W., van Dongen, Jacques J. M., Murre, Cornelis, van Zelm, Menno C.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705691/
https://ncbi.nlm.nih.gov/pubmed/26384565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv928
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