The 3D Structure of the Immunoglobulin Heavy-Chain Locus: Implications for Long-Range Genomic Interactions

The immunoglobulin heavy-chain (Igh) locus is organized into distinct regions that contain multiple variable (V(H)), diversity (D(H)), joining (J(H)) and constant (C(H)) coding elements. How the Igh locus is structured in 3D space is unknown. To probe the topography of the Igh locus, spatial distanc...

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Main Authors: Jhunjhunwala, Suchit, van Zelm, Menno C., Peak, Mandy M., Cutchin, Steve, Riblet, Roy, van Dongen, Jacques J.M., Grosveld, Frank G., Knoch, Tobias A., Murre, Cornelis
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771211/
https://ncbi.nlm.nih.gov/pubmed/18423198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.03.024
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