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Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme

A requirement for specific RNA folding is that the free-energy landscape discriminate against non-native folds. While tertiary interactions are critical for stabilizing the native fold, they are relatively non-specific, suggesting additional mechanisms contribute to tertiary folding specificity. In...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Mustoe, Anthony M., Al-Hashimi, Hashim M., Brooks, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705646/
https://ncbi.nlm.nih.gov/pubmed/26481360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1055
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