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A non-canonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding

Mammalian mitochondrial tRNA(Ser(UCN)) (mt-tRNA(Ser)) and pyrrolysine tRNA (tRNA(Pyl)) fold to near-canonical three-dimensional structures despite having non-canonical secondary structures with shortened interhelical loops that disrupt the conserved tRNA tertiary interaction network. How these non-c...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Mustoe, Anthony M., Liu, Xin, Lin, Paul J., Al-Hashimi, Hashim M., Fierke, Carol A., Brooks, Charles L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399864/
https://ncbi.nlm.nih.gov/pubmed/25705930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5130308
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