Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform

T-cell–directed killing of tumor cells using bispecific antibodies is a promising approach for the treatment of hematologic malignancies. Here we describe our preclinical work with a dual-affinity retargeting (DART) molecule generated from antibodies to CD3 and CD123, designed to redirect T cells ag...

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Udgivet i:Blood
Main Authors: Al-Hussaini, Muneera, Rettig, Michael P., Ritchey, Julie K., Karpova, Darja, Uy, Geoffrey L., Eissenberg, Linda G., Gao, Feng, Eades, William C., Bonvini, Ezio, Chichili, Gurunadh R., Moore, Paul A., Johnson, Syd, Collins, Lynne, DiPersio, John F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705603/
https://ncbi.nlm.nih.gov/pubmed/26531164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-575704
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