Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform

T-cell–directed killing of tumor cells using bispecific antibodies is a promising approach for the treatment of hematologic malignancies. Here we describe our preclinical work with a dual-affinity retargeting (DART) molecule generated from antibodies to CD3 and CD123, designed to redirect T cells ag...

Full description

Saved in:
Bibliographic Details
Published in:Blood
Main Authors: Al-Hussaini, Muneera, Rettig, Michael P., Ritchey, Julie K., Karpova, Darja, Uy, Geoffrey L., Eissenberg, Linda G., Gao, Feng, Eades, William C., Bonvini, Ezio, Chichili, Gurunadh R., Moore, Paul A., Johnson, Syd, Collins, Lynne, DiPersio, John F.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2016
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705603/
https://ncbi.nlm.nih.gov/pubmed/26531164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-575704
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items