Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform

T-cell–directed killing of tumor cells using bispecific antibodies is a promising approach for the treatment of hematologic malignancies. Here we describe our preclinical work with a dual-affinity retargeting (DART) molecule generated from antibodies to CD3 and CD123, designed to redirect T cells ag...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Al-Hussaini, Muneera, Rettig, Michael P., Ritchey, Julie K., Karpova, Darja, Uy, Geoffrey L., Eissenberg, Linda G., Gao, Feng, Eades, William C., Bonvini, Ezio, Chichili, Gurunadh R., Moore, Paul A., Johnson, Syd, Collins, Lynne, DiPersio, John F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2016
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705603/
https://ncbi.nlm.nih.gov/pubmed/26531164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-575704
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