Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform

T-cell–directed killing of tumor cells using bispecific antibodies is a promising approach for the treatment of hematologic malignancies. Here we describe our preclinical work with a dual-affinity retargeting (DART) molecule generated from antibodies to CD3 and CD123, designed to redirect T cells ag...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Al-Hussaini, Muneera, Rettig, Michael P., Ritchey, Julie K., Karpova, Darja, Uy, Geoffrey L., Eissenberg, Linda G., Gao, Feng, Eades, William C., Bonvini, Ezio, Chichili, Gurunadh R., Moore, Paul A., Johnson, Syd, Collins, Lynne, DiPersio, John F.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2016
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705603/
https://ncbi.nlm.nih.gov/pubmed/26531164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-575704
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