Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

The CXCR4–SDF-1 axis plays a central role in the trafficking and retention of normal and malignant stem cells in the bone marrow (BM) microenvironment. Here, we used a mouse model of acute promyelocytic leukemia (APL) and a small molecule competitive antagonist of CXCR4, AMD3100, to examine the inte...

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Bibliografiske detaljer
Main Authors:	Nervi, Bruno, Ramirez, Pablo, Rettig, Michael P., Uy, Geoffrey L., Holt, Matthew S., Ritchey, Julie K., Prior, Julie L., Piwnica-Worms, David, Bridger, Gary, Ley, Timothy J., DiPersio, John F.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society of Hematology 2009
Fag:	Myeloid Neoplasia
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2699239/ https://ncbi.nlm.nih.gov/pubmed/19050309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-162123
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Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

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