Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

The CXCR4–SDF-1 axis plays a central role in the trafficking and retention of normal and malignant stem cells in the bone marrow (BM) microenvironment. Here, we used a mouse model of acute promyelocytic leukemia (APL) and a small molecule competitive antagonist of CXCR4, AMD3100, to examine the inte...

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Hauptverfasser: Nervi, Bruno, Ramirez, Pablo, Rettig, Michael P., Uy, Geoffrey L., Holt, Matthew S., Ritchey, Julie K., Prior, Julie L., Piwnica-Worms, David, Bridger, Gary, Ley, Timothy J., DiPersio, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2009
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699239/
https://ncbi.nlm.nih.gov/pubmed/19050309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-162123
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