PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer

Tumour cells can use strategies that make them resistant to nutrient deprivation to outcompete their neighbours. A key integrator of the cell's responses to starvation and other stresses is amino-acid-dependent mechanistic target of rapamycin complex 1 (mTORC1). Activation of mTORC1 on late end...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Fan, S-J, Snell, C, Turley, H, Li, J-L, McCormick, R, Perera, S M W, Heublein, S, Kazi, S, Azad, A, Wilson, C, Harris, A L, Goberdhan, D C I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705441/
https://ncbi.nlm.nih.gov/pubmed/26434594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.363
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