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Proton-assisted amino acid transporters are conserved regulators of proliferation and amino acid-dependent mTORC1 activation
The PI3-kinase (PI3K)/Akt and downstream mammalian target of rapamycin complex 1 (mTORC1) signalling cascades promote normal growth and are frequently hyperactivated in tumour cells. mTORC1 is also regulated by local nutrients, particularly amino acids, but the mechanisms involved are poorly underst...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018277/ https://ncbi.nlm.nih.gov/pubmed/20498635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.177 |
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