Proton-assisted amino acid transporters are conserved regulators of proliferation and amino acid-dependent mTORC1 activation

The PI3-kinase (PI3K)/Akt and downstream mammalian target of rapamycin complex 1 (mTORC1) signalling cascades promote normal growth and are frequently hyperactivated in tumour cells. mTORC1 is also regulated by local nutrients, particularly amino acids, but the mechanisms involved are poorly underst...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Heublein, S, Kazi, S, Ögmundsdóttir, M H, Attwood, E V, Kala, S, Boyd, C A R, Wilson, C, Goberdhan, D C I
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018277/
https://ncbi.nlm.nih.gov/pubmed/20498635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.177
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados