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Proton-assisted amino acid transporters are conserved regulators of proliferation and amino acid-dependent mTORC1 activation
The PI3-kinase (PI3K)/Akt and downstream mammalian target of rapamycin complex 1 (mTORC1) signalling cascades promote normal growth and are frequently hyperactivated in tumour cells. mTORC1 is also regulated by local nutrients, particularly amino acids, but the mechanisms involved are poorly underst...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018277/ https://ncbi.nlm.nih.gov/pubmed/20498635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.177 |
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