Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation

Monoglyceride lipase (MGL) is required for efficient hydrolysis of the endocannabinoid 2-arachidonoylglyerol (2-AG) in the brain generating arachidonic acid (AA) and glycerol. This metabolic function makes MGL an interesting target for the treatment of neuroinflammation, since 2-AG exhibits anti-inf...

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Vydáno v:J Biol Chem
Hlavní autoři: Grabner, Gernot F., Eichmann, Thomas O., Wagner, Bernhard, Gao, Yuanqing, Farzi, Aitak, Taschler, Ulrike, Radner, Franz P. W., Schweiger, Martina, Lass, Achim, Holzer, Peter, Zinser, Erwin, Tschöp, Matthias H., Yi, Chun-Xia, Zimmermann, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705409/
https://ncbi.nlm.nih.gov/pubmed/26565024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.683615
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