Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity

BACKGROUND AND PURPOSE: Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB(1/2)). Because the CB(1) receptor is involved in the control of gut function, we investigated the effects of pharmacological inhibition and genetic deletion...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Taschler, U, Eichmann, T O, Radner, F P W, Grabner, G F, Wolinski, H, Storr, M, Lass, A, Schicho, R, Zimmermann, R
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2015
Teme:
Research Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556478/
https://ncbi.nlm.nih.gov/pubmed/26075589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13224
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items