Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation

Infantile hemangiomas (IHs) are the most common vascular tumor and arise from a hemangioma stem cell (HemSC). Propranolol has proved efficacious for problematic IHs. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist that can lower cAMP levels and activate the mitogen-activated pro...

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Vydáno v:Stem Cells Transl Med
Hlavní autoři: Munabi, Naikhoba C.O., England, Ryan W., Edwards, Andrew K., Kitajewski, Alison A., Tan, Qian Kun, Weinstein, Andrew, Kung, Justin E., Wilcox, Maya, Kitajewski, Jan K., Shawber, Carrie J., Wu, June K.
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2016
Témata:
Tissue-Specific Progenitor and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704871/
https://ncbi.nlm.nih.gov/pubmed/26574555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0076
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