Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation

Infantile hemangiomas (IHs) are the most common vascular tumor and arise from a hemangioma stem cell (HemSC). Propranolol has proved efficacious for problematic IHs. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist that can lower cAMP levels and activate the mitogen-activated pro...

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Udgivet i:Stem Cells Transl Med
Main Authors: Munabi, Naikhoba C.O., England, Ryan W., Edwards, Andrew K., Kitajewski, Alison A., Tan, Qian Kun, Weinstein, Andrew, Kung, Justin E., Wilcox, Maya, Kitajewski, Jan K., Shawber, Carrie J., Wu, June K.
Format: Artigo
Sprog:Inglês
Udgivet: AlphaMed Press 2016
Fag:
Tissue-Specific Progenitor and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704871/
https://ncbi.nlm.nih.gov/pubmed/26574555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0076
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