The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients

INTRODUCTION: HLA-B*35 is associated with increased risk of developing pulmonary hypertension in SSc patients. We previously reported that HLA-B*35 induces endothelial cell dysfunction via activation of ER stress/UPR and upregulation of the inflammatory response. Because PBMCs from lcSSc-PAH patient...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arthritis Res Ther
Prif Awduron: Lenna, Stefania, Assassi, Shervin, Farina, G. Alessandra, Mantero, Julio C., Scorza, Raffaella, Lafyatis, Robert, Farber, Harrison W., Trojanowska, Maria
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704539/
https://ncbi.nlm.nih.gov/pubmed/26669670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0881-1
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