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HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells

The presence of the HLA-B35 allele has emerged as an important risk factor for the development of isolated pulmonary hypertension in patients with scleroderma, however the mechanisms underlying this association have not been fully elucidated. The goal of our study was to determine the molecular mech...

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Bibliografische gegevens
Hoofdauteurs: Lenna, Stefania, Townsend, Danyelle M., Tan, Filemon K., Kapanadze, Bagrat, Markiewicz, Malgorzata, Trojanowska, Maria, Scorza, Raffaella
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836507/
https://ncbi.nlm.nih.gov/pubmed/20335527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903188
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