The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients

INTRODUCTION: HLA-B*35 is associated with increased risk of developing pulmonary hypertension in SSc patients. We previously reported that HLA-B*35 induces endothelial cell dysfunction via activation of ER stress/UPR and upregulation of the inflammatory response. Because PBMCs from lcSSc-PAH patient...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Lenna, Stefania, Assassi, Shervin, Farina, G. Alessandra, Mantero, Julio C., Scorza, Raffaella, Lafyatis, Robert, Farber, Harrison W., Trojanowska, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704539/
https://ncbi.nlm.nih.gov/pubmed/26669670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0881-1
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