E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

Previous studies have shown that the carboxyl-terminal region of E2F-1 (residues 368-437) can support transcriptional activation when linked to the DNA-binding domain of the yeast transcription factor GAL4. This region also contains an 18-residue retinoblastoma (RB)-binding sequence, raising the pos...

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Bibliographic Details
Main Authors: Flemington, E K, Speck, S H, Kaelin, W G
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC47045/
https://ncbi.nlm.nih.gov/pubmed/8346196
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