Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.
The transcription factor E2F is present in independent complexes with the product of the retinoblastoma susceptibility gene, pRB, and a related gene product, p107, in association with the cyclin A-cdk2 or the cyclin E-cdk2 kinase complex. pRB and p107 can negatively regulate E2F activity, since over...
Guardat en:
| Publicat a: | Mol Cell Biol |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
1993
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364797/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8246949/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.12.7267-7277.1993 |
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