Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages

Here we describe the development and validation of an intracellular high-throughput screening assay for finding new antituberculosis compounds active in human macrophages. The assay consists of a luciferase-based primary identification assay, followed by a green fluorescent protein-based secondary p...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Sorrentino, Flavia, Gonzalez del Rio, Ruben, Zheng, Xingji, Presa Matilla, Jesus, Torres Gomez, Pedro, Martinez Hoyos, Maria, Perez Herran, Maria Esther, Mendoza Losana, Alfonso, Av-Gay, Yossef
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704166/
https://ncbi.nlm.nih.gov/pubmed/26503663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01920-15
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